1158759-03-5, tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step a: To a solution of 2-chloro-4-((4-methoxybenzyl)oxy)pyrimidine (118 mg, 0.5 19 mmol), prepared according to the methods in W0201 1022440, in DMF (50 mL) was added tert-butyl ((4-methylpiperidin-4-yl)methyl)carbamate (130 mg, 0.5 19 mmol). The reaction stirred for 48 h and was diluted in EtOAc:water (1:1, 100 mL). The mixture was extracted with EtOAc (3 x) and the combined organic extracts were washed with brine (3 x), dried over Mg504, filtered, and concentrated under reduced pressure to afford crude tert-butyl ((1 -(4-((4- methoxybenzyl)oxy)pyrimidin-2-yl)-4-methylpiperidin-4-yl)methyl)carbamate, as a yellow oil (202 mg) which was used without further purification. MS m/z 443 (M+H).
1158759-03-5, The synthetic route of 1158759-03-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Piperidine – Wikipedia
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