With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.
General procedure: To a stirring mixture of 4-(2-morpholinoethoxy)benzaldehyde(0.235 g, 1 mmol) and malononitrile (0.132 g,2 mmol) dissolved in 10 cm3 EtOH, in the presence ofNiFe2O4 NPs (0.012 g, 5 mol%), dimedone (0.140 g,1 mmol) was added. The mixture was heated under refluxconditions for the time indicated in Table II. After completionof reaction which was found out by monitoring onTLC, the mixture was poured into boiling THF (10 mL)and then the catalyst was separated by a magnet, washedwith boiling acetone (5 cm3, and dried at 100 C for1 h to use in further cycles. The mixture was evaporatedto obtain crude product. In final step, crud product was recrystallized in boiling EtOH to afford crystalline pureproduct 4a., 10338-57-5
10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; Amiri, Mahnaz; Asadipour, Ali; Eskandari, Khalil; Faghih-Mirzaei, Ehsan; Khodadadi, Arash; Morsali, Laleh; Pourshojaei, Yaghoub; Shamsimeymandi, Reza; Talebi, Mahshid; Zolala, Fatemeh; Journal of Nanoscience and Nanotechnology; vol. 20; 5; (2020); p. 3206 – 3216;,
Piperidine – Wikipedia
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