Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, molecular formula is C14H18N4. In an article, author is Kirichok, Alexander A.,once mentioned of 401566-79-8, Name: 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.
Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery
The synthesis of multifunctional spirocycles was achieved from common cyclic carboxylic acids (cyclobutane carboxylate, cyclopentane carboxylate, l-proline, etc.). The whole sequence included only two chemical stepssynthesis of azetidinones, and reduction into azetidines. The obtained spirocyclic amino acids were incorporated into a structure of the known anesthetic drug Bupivacaine. The obtained analogues were more active and less toxic than the original drug. We believe that this discovery will lead to a wide use of spirocyclic building blocks in drug discovery in the near future.
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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem