Chemistry is an experimental science, SDS of cas: 27578-60-5, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 27578-60-5, Name is N-(2-Aminoethyl)piperidine
Synthesis, biological evaluation, and structure-activity relationships of potent noncovalent and nonpeptidic cruzain inhibitors as anti-Trypanosoma cruzi agents
The development of cruzain inhibitors has been driven by the urgent need to develop novel and more effective drugs for the treatment of Chagas’ disease. Herein, we report the lead optimization of a class of noncovalent cruzain inhibitors, starting from an inhibitor previously cocrystallized with the enzyme (Ki = 0.8 muM). With the goal of achieving a better understanding of the structure-activity relationships, we have synthesized and evaluated a series of over 40 analogues, leading to the development of a very promising competitive inhibitor (8r, IC50 = 200 nM, Ki = 82 nM). Investigation of the in vitro trypanocidal activity and preliminary cytotoxicity revealed the potential of the most potent cruzain inhibitors in guiding further medicinal chemistry efforts to develop drug candidates for Chagas’ disease.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. SDS of cas: 27578-60-5, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 27578-60-5, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H4332N – PubChem