Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 177-11-7, molcular formula is C7H13NO2, introducing its new discovery. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane
Class III antiarrhythmic agents have been shown to prevent reentrant arrhythmias but also to be responsible for initiating arrhythmias characterised by afterdepolarizations and triggered activities. By combining potassium and calcium channel antagonistic actions, as with BRL-32872 (1), it might be possible to reduce the incidence of proarrhythmias albeit retaining antiarrhythmic efficacy. In the present study we synthesised and tested for their electrophysiological activity in guinea pig papillary muscle a wide panel of analogues of BRL-32872. Some qualitative relationships between compound structure and the inhibitory effect on the rapidly activating component of the delayed rectifier potassium current and/or the l-type calcium current will be presented. New derivatives depicting bell-shaped dose-response curves on action potential duration may therefore represent novel agents for improved antiarrhythmic therapy. Copyright (C) 1998 Elsevier Science Ltd.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 177-11-7
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Piperidine – Wikipedia,
Piperidine | C5H7653N – PubChem