Recommanded Product: 177-11-7. Recently I am researching about ENCODED CHEMICAL LIBRARIES; MEDICINAL CHEMISTRY; HYDROGEN-PEROXIDE; DNA; DESIGN; SULFONAMIDES; DRUGS; INHIBITOR; DISCOVERY; SULFONES, Saw an article supported by the NCATS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Center for Advancing Translational Sciences (NCATS) [TL1 TR002551] Funding Source: Medline; NIGMS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R35 GM118176] Funding Source: Medline; NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [1S10OD025208, S10 OD025208] Funding Source: Medline. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Flood, DT; Zhang, XJ; Fu, X; Zhao, ZX; Asai, S; Sanchez, BB; Sturgell, EJ; Vantourout, JC; Richardson, P; Flanagan, ME; Piotrowski, DW; Kolmel, DK; Wan, JQ; Tsai, MH; Chen, JSS; Baran, PS; Dawson, PE. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane
DNA encoded libraries (DEL) have shown promise as a valuable technology for democratizing the hit discovery process. Although DEL provides relatively inexpensive access to libraries of unprecedented size, their production has been hampered by the idiosyncratic needs of the encoding DNA tag relegating DEL compatible chemistry to dilute aqueous environments. Recently reversible adsorption to solid support (RASS) has been demonstrated as a promising method to expand DEL reactivity using standard organic synthesis protocols. Here we demonstrate a suite of on-DNA chemistries to incorporate medicinally relevant and C-S, C-P and N-S linkages into DELs, which are underrepresented in the canonical methods.
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Reference：
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Piperidine | C5H7510N – PubChem