Sobolewski, Dariusz et al. published their research in Journal of Peptide Science in 2009 | CAS: 86069-86-5

Analogues of AVP modified in the N-terminal part of the molecule with Pip isomers: TFA-catalyzed peptide bond hydrolysis was written by Sobolewski, Dariusz;Prahl, Adam;Kwiatkowska, Anna;Slaninova, Jirina;Lammek, Bernard. And the article was included in Journal of Peptide Science in 2009.Category: piperidines The following contents are mentioned in the article:

Using SPPS techniques, six new analogs of AVP (arginine vasopressin) and some of its agonists were synthesized. The peptides were designed by substitution of Phe at position 3 of AVP, [Mpa¹] AVP (dAVP) and [Mpa¹,Val⁴,D-Arg⁸]VP (dVDAVP) with L– or D-Pip (Mpa = 3-mercaptopropionic acid; Pip = pipecolic acid, a non-coded α-imino acid, also known as homoproline). Surprisingly enough, both the analogs of AVP and [Mpa¹]AVP with identical substituents at position 2 turned out to be highly sensitive to TFA used for the deprotection and resin cleavage step, and it was the reason why the authors were not able to obtain these four peptides. The mechanisms of their fragmentation were proposed in this study. Unfortunately, all the new analogs were inactive in bioassays for the pressor, antidiuretic and uterotonic in vitro activities in the rat. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Category: piperidines).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem