Sluder, Ann published the artcileSpiroindolines identify the vesicular acetylcholine transporter as a novel target for insecticide action, HPLC of Formula: 637362-21-1, the main research area is spiroindoline insecticide target vesicular acetylcholine transporter.
The efficacy of all major insecticide classes continues to be eroded by the development of resistance mediated, in part, by selection of alleles encoding insecticide insensitive target proteins. The discovery of new insecticide classes acting at novel protein binding sites is therefore important for the continued protection of the food supply from insect predators, and of human and animal health from insect borne disease. Here we describe a novel class of insecticides (Spiroindolines) encompassing mols. that combine excellent activity against major agricultural pest species with low mammalian toxicity. We confidently assign the vesicular acetylcholine transporter as the mol. target of Spiroindolines through the combination of mol. genetics in model organisms with a pharmacol. approach in insect tissues. The vesicular acetylcholine transporter can now be added to the list of validated insecticide targets in the acetylcholine signaling pathway and we anticipate that this will lead to the discovery of novel mols. useful in sustaining agriculture. In addition to their potential as insecticides and nematocides, Spiroindolines represent the only other class of chem. ligands for the vesicular acetylcholine transporter since those based on the discovery of vesamicol over 40 years ago, and as such, have potential to provide more selective tools for PET imaging in the diagnosis of neurodegenerative disease. They also provide novel biochem. tools for studies of the function of this protein family.
PLoS One published new progress about Caenorhabditis elegans. 637362-21-1 belongs to class piperidines, name is tert-Butyl 5-chlorospiro[indoline-3,4′-piperidine]-1′-carboxylate, and the molecular formula is C17H23ClN2O2, HPLC of Formula: 637362-21-1.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem