Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors was written by Singh, Baljinder;Bernatchez, Jean A.;McCall, Laura-Isobel;Calvet, Claudia M.;Ackermann, Jasmin;Souza, Julia M.;Thomas, Diane;Silva, Everton M.;Bachovchin, Kelly A.;Klug, Dana M.;Jalani, Hitesh B.;Bag, Seema;Buskes, Melissa J.;Leed, Susan E.;Roncal, Norma E.;Penn, Erica C.;Erath, Jessey;Rodriguez, Ana;Sciotti, Richard J.;Campbell, Robert F.;McKerrow, James;Siqueira-Neto, Jair L.;Ferrins, Lori;Pollastri, Michael P.. And the article was included in ACS Medicinal Chemistry Letters in 2020.Application of 41838-46-4 This article mentions the following:
Utilizing a target repurposing and parasite-hopping approach, we tested a previously reported library of compounds that were active against Trypanosoma brucei, plus 31 new compounds, against a variety of protozoan parasites including Trypanosoma cruzi, Leishmania major, Leishmania donovani, and Plasmodium falciparum. This led to the discovery of several compounds with submicromolar activities and improved physicochem. properties that are early leads toward the development of chemotherapeutic agents against kinetoplastid diseases and malaria. In the experiment, the researchers used many compounds, for example, 4-Amino-1-methylpiperidine (cas: 41838-46-4Application of 41838-46-4).
4-Amino-1-methylpiperidine (cas: 41838-46-4) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Application of 41838-46-4
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem