Simple exploration of (R)-Benzyl 3-hydroxypiperidine-1-carboxylate

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Synthetic Route of 100858-34-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.100858-34-2, Name is (R)-Benzyl 3-hydroxypiperidine-1-carboxylate, molecular formula is C13H17NO3. In a article£¬once mentioned of 100858-34-2

Enantioselective Synthesis of Chiral Piperidines via the Stepwise Dearomatization/Borylation of Pyridines

We have developed a novel approach for the synthesis of enantioenriched 3-boryl-tetrahydropyridines via the Cu(I)-catalyzed regio-, diastereo-, and enantioselective protoborylation of 1,2-dihydropyridines, which were obtained by the partial reduction of the pyridine derivatives. This dearomatization/enantioselective borylation stepwise strategy provides facile access to chiral piperidines together with the stereospecific transformation of a stereogenic C-B bond from readily available starting materials. Furthermore, the utility of this method is demonstrated for the concise synthesis of the antidepressant drug (-)-paroxetine. A theoretical study of the reaction mechanism is also described.

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H19003N – PubChem