The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. SDS of cas: 14047-28-0, 14047-28-0, Name is (R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol, SMILES is C[C@@H](O)CN1C=NC2=C(N)N=CN=C12, in an article , author is Bamborough, Paul, once mentioned of 14047-28-0.
Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors
ATAD2 is a cancer-associated protein whose bromodomain has been described as among the least druggable of its class. In our recent disclosure of the first chemical probe against this bromodomain, GSK8814 (6), we described the use of a conformationally constrained methoxy piperidine to gain selectivity over the BET bromodomains. Here we describe an orthogonal conformational restriction strategy of the piperidine ring to give potent and selective tropane inhibitors and show structural insights into why this was more challenging than expected. Greater understanding of why different rational approaches succeeded or failed should help in the future design of selectivity in the bromodomain family.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 14047-28-0, you can contact me at any time and look forward to more communication. SDS of cas: 14047-28-0.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem