Chemistry is an experimental science, Formula: C7H13NO2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2971-79-1, Name is Methyl piperidine-4-carboxylate
Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease
We describe a series of potent and highly selective small-molecule MALT1 inhibitors, optimized from a High-Throughput Screening hit. Advanced analogues such as compound 40 show high potency (IC50: 0.01 muM) in a biochemical assay measuring MALT1 enzymatic activity, as well as in cellular assays: Jurkat T cell activation (0.05 muM) and IL6/10 secretion (IC50: 0.10/0.06 muM) in the TMD8 B-cell lymphoma line. Compound 40 also inhibited cleavage of the MALT1 substrate RelB (IC50: 0.10 muM). Mechanistic enzymology results suggest that these compounds bind to the known allosteric site of the protease.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C7H13NO2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2971-79-1, in my other articles.
Reference£º
Piperidine – Wikipedia,
Piperidine | C5H7883N – PubChem