914988-10-6, tert-Butyl 3-cyano-4-oxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
914988-10-6, A mixture of tert-butyl 3 -cyano-4-oxopiperidine- 1 -carboxylate (310 g, 1.38 mol) and hydrazine mono-hydrate (140 mL, 2.08 mol) in EtOH (1.5 L) was heated to 60 C for 2 h. The mixture was concentrated in vacuo to give the crude product that was dissolved in EtOAc (1 L) and washed with water (1 L x 2). The organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo to afford the title compound (230 g, 70%) as a colorless solid. ?HNMR (400 IVIHz, CD3OD) 4.28 (s, 2H), 3.66- 3.63 (m, 2H), 2.62-2.59 (m, 2H), 1.49 (s, 9H).
The synthetic route of 914988-10-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; CYR, Patrick; BRONNER, Sarah; ROMERO, F. Anthony; MAGNUSON, Steven; TSUI, Vickie Hsiao-Wei; MURRAY, Jeremy M.; WAI, John; LAI, Kwong Wah; WANG, Fei; CHEN, Kevin X.; (351 pag.)WO2017/205538; (2017); A1;,
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