89895-06-7, 1-(Piperidin-4-yl)ethanone hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
89895-06-7, Step 1: methyl 2-(4-bromophenyl)acetate (200 mg, 0.87 mmol) was dissolved in dry toluene (10 mL). The mixture was purged with nitrogen. 4-Acetyl-piperidine hydrochloride (286 mg, 1 .75 mmol), Pd2(dba)3 (40 mg, 0.044 mmol), XPhos (42 mg, 0.088 mmol) and Cs2003 (710 mg, 2.19 mmol) were added and themixture was heated to 90C for 16h. The solution was cooled to rt and filtered through a pad of Celite and the filtrate was concentrated to dryness. The crude material was purified by column chromatography eluting with heptane and a gradient of heptane/EtOAc from [100:0] to [20:80]. The product fractions were combined and the solution was concentrated to dryness to afford methyl 2-[4-(4- acetylpiperidin-1-yl)phenyl]acetate (226 mg, 94%) as colourless oil.
The synthetic route of 89895-06-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GENFIT; DELHOMEL, Jean-Francois; PERSPICACE, Enrico; MAJD, Zouher; PARROCHE, Peggy; WALCZAK, Robert; BONNET, Pascal; FOGHA, Jade; (82 pag.)WO2018/138354; (2018); A1;,
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