883984-95-0, Benzyl 7′-chloro-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
INTERMEDIATE 13 r-Methylspiro[piperidine-4,4′-pyridor2.3-6?[l,31oxazinl-2Yrff)-oneStep A. Benzyl 7′-chloro-r-methyl-2′-oxo-r.2′-dihydro-lH-spiro[piperidine-4,4′-pyrido[2,3- d [1 ,3″|oxazine]-l -carboxylate; To a 0 C solution of benzyl 7′-chloro-2′-oxo-ll,2′-dihydro-lH-spiro[piperidine- 4,4′-pyrido[2,3-<^[l,3]oxazine]-l-carboxylate (0.56 g, 1.43 mmol) in DMF (14 niL) was added lithium bis(trimethylsilyl)amide (2.86 mL of IM solution, 2.86 mmol) followed by methyl iodide (0.11 mL, 2.28 mmol). After Ih, more methyl iodide was added (0.55 mL, 1.14 mmol). After a further Ih, the reaction was diluted with EtOAc, extracted with water (3x) and brine, dried over MgSO4, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel chromatography, eluting with a gradient of 0 to 4% methanol : dichloromethane to give the title compound (0.47 g). MS 402.0 (M + 1). 883984-95-0, The synthetic route of 883984-95-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK & CO., INC.; WO2006/44504; (2006); A1;,
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