Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Application In Synthesis of 8-Boc-2,8-Diazaspiro[4.5]decane, Which mentioned a new discovery about 236406-39-6
The inhibition of beta secretase (BACE1) is potentially important approach to treatment of Alzheimer disease (AD). A novel series of 4-bromophenyl piperazine derivatives coupled to the phenylimino-2H-chromen-3-carboxamide scaffold were investigated as BACE1 inhibitors in this study. Docking study suggested that the phenyl-imino group of the scaffold establishes favorable pi-pi stacking interaction with side chain of Phe108 of flap pocket. Some of the docking proposed derivatives were synthesized and evaluated for BACE1 inhibitory activity using a FRET-based assay. High BACE1 inhibitory activities were observed from derivatives containing fused heteroaromtic groups attached through the aliphatic linkage to the N4-piperazine moiety, which may be attributed to the engagement of effective interactions with S1-S’1 sub-pocket residues. Of the most potent compounds, 9e displayed an IC50 value for BACE1 of 98 nM. Some of these derivatives demonstrated good inhibitory activity on Abeta production in N2a-APPswe cells at 5 and 10 muM. These compounds might be considered as promising BACE1 inhibitory agents that could lower Abeta production in AD.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Application In Synthesis of 8-Boc-2,8-Diazaspiro[4.5]decane, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 236406-39-6
Reference：
Piperidine – Wikipedia,
Piperidine | C5H19502N – PubChem