With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.768-66-1,2,2,6,6-Tetramethylpiperidine,as a common compound, the synthetic route is as follows.,768-66-1
2,3-Dichloro-4-iodo-pyridine (I-1) To a solution of n-BuLi (27.6 mL, 69 mmol, 2.5 M in hexanes) in dry Et2O (150 mL) cooled at -78 C., under a nitrogen atmosphere, was added 2,2,6,6-tetramethylpiperidine (11.64 mL, 69 mmol) dropwise. The resulting r.m. was stirred at -78 C. for 10 min, and then a solution of 2,3-dichloropyridine (10 g, 67.57 mmol) in dry THF (75 mL) was added dropwise. The mixture was stirred at -78 C. for 30 min and then a solution of iodine (25.38 g, 100 mmol) in dry THF (75 mL) was added. The mixture was allowed to warm to r.t. overnight, quenched with Na2S2O3 (aq sat. sol.) and extracted twice with EtOAc. The combined organic extracts were washed with NaHCO3 (aq. sat. sol.), dried (Na2SO4) and concentrated in vacuo. The crude residue was precipitated with heptane, filtered off and dried to yield intermediate I-1 (8.21 g, 44%) as a pale cream solid.
768-66-1 2,2,6,6-Tetramethylpiperidine 13035, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; Janssen Pharmaceuticals, Inc.; Andres-Gil, Jose Ignacio; Alcazar-Vaca, Manuel Jesus; Cid-Nunez, Jose Maria; Trabanco-Suarez, Andres Avelino; Bormans, Guy Maurits R.; Celen, Sofie Jeanne Leopoldine; Koole, Michel; US2013/230459; (2013); A1;,
Piperidine – Wikipedia
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