73874-95-0, tert-Butyl piperidin-4-ylcarbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of tert- vXy piperidin-4-ylcarbamate (3.00 g, 15.00 mmol), 6- chloronicotinonitrile (2.08 g, 15.00 mmol) and Na2C03(3.20 g, 30.19 mmol) in DMF (40 mL) was heated to 90 C and stirred for 4 h. The reaction mixture was cooled to room temperature, diluted with water (120 mL), and extracted with EtOAc (100 mL x 3). The combined organic phases were washed with brine (300 mL), dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was washed with PE/EtOAc (10/1 (v/v), 80 mL) to give the title compound as a white solid (4.50 g, 99 %).MS ( ESI, pos. ion) m/z: 247.0 [M-C4H8+ H]+; H NMR (400 MHz, CDCb): delta (ppm) 8.40 (d, J = 2.36 Hz, 1H), 7.62-7.59 (dd, J = 2.36 Hz, 9.08 Hz, 1H), 6.63 (d, J = 9.08 Hz, 1H), 4.45 (m, 1H), 4.36-4.33 (m, 2H), 3.75 (m, 1H), 3.14-3.07 (m, 2H), 2.08-2.06 (m, 2H), 1.45 (s, 9H), 1.43-1.37 (m, 2H)., 73874-95-0
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Reference£º
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Minxiong; LI, Xiaobo; WO2015/73267; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem