With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7149-42-0,(1-Methylpiperidin-4-yl)methanamine,as a common compound, the synthetic route is as follows.
General procedure: Exam le: Synthesis of final product 1A mixture of (1-methyl-4-piperidinyl)methanamine (101 mg, 0.78 mmol) and Intermediate 1-42 (100 mg, 0.26 mmol) in DMA (5 mL) was heated at 100 C for 8 h. The solvents were removed in vacuo and the residue was purified by column chromatography (DCM/7N NH3 in MeOH 100:0 to 98:2). The product obtained was triturated from Et20 to afford Final Product 1 (32 mg) as a white solid., 7149-42-0
The synthetic route of 7149-42-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); MCNEENEY, Stephen, Phillip; PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALES, Sonia; MARTIN HERNANDO, Jose Ignacio; RODRIGUEZ HERGUETA, Antonio; RICO FERREIRA, Maria del Rosario; BLANCO APARICIO, Carmen; WO2013/4984; (2013); A1;,
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