63921-23-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63921-23-3,1-Phenylpiperidin-4-amine,as a common compound, the synthetic route is as follows.
Example 21 (397mg, lmmol), 1-phenylpiperidin-4-ylamine (176mg, Immol) and silver acetate (167mg, lmmol) in acetonitrile (20ml) were heated at reflux overnight. The reaction mixture was evaporated, purified by column chromatography on silica using 2-10% methanol in dichloromethane as the eluant, followed by mass triggered HPLC purification using an acid based eluant. The free base was liberated using a strong cation exchange cartridge to give the desired compound (40mg). 1H NMR 8 (ppm) 400MHz (CDC13), 1.45-1. 52 (2 H, m), 2.00-2. 13 (4 H, m), 2.32- 2.52 (5 H, m), 2.74-2. 80 (2 H, m), 3.25-3. 31 (2 H, m), 3.37-3. 46 (1 H, m), 3.55-3. 76 (4 H, m), 6.82-6. 93 (5 H, m), 7.14 (1 H, dd, J = 4.7, 7.4Hz), 7.23-7. 27 (2 H, m), 7.48 – 7. 52 (3 H, m), 8.37 (1 H, d, J = 4.3Hz). MSp m/z for MH+ =540.
63921-23-3 1-Phenylpiperidin-4-amine 21193347, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; MERCK SHARP & DOHME LIMITED; WO2005/51390; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem