With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62718-28-9,1-Methylpiperidine-4-carboxamide,as a common compound, the synthetic route is as follows.
Intermediate 20: step a 1-Methylpiperidine-4-carbothioamide To a suspension of 1-methylpiperidine-4-carboxamide (3.97 g, 27.9 mmol, Amfinecom) in a mixture of toluene (70 mL) and THF (30 mL) was added Lawesson’s reagent (6.78 g, 16.8 mmol). The resulting light yellow suspension was heated at reflux for 22 h. The reaction mixture was diluted with DCM and MeOH and was concentrated onto silica gel for purification by column chromatography (Silica gel, 1-8% MeOH in 98:2 DCM:conc. aq. NH4OH, water layer removed in a separatory funnel), affording the title compound as a yellow solid.
62718-28-9 1-Methylpiperidine-4-carboxamide 339011, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; JACKSON, Paul Francis; Manthey, Carl; Rhodes, Kenneth; Scannevin, Robert; Leonard, Kristi Anne; Barbay, Joseph Kent; Todd, Matthew; Springer, Barry A.; US2012/302573; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem