6091-44-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6091-44-7,Piperidine hydrochloride,as a common compound, the synthetic route is as follows.
piperidine hydrochloride (4.4 mg, 0.04 mmol) was added to a solution of trans-(RS)-alpha-methyl-N-[4(2,4-dioxopiperidin-1-yl)-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide (Example 266, 20 mg, 0.04 mmol) in methanol (1 ML) and the mixture was stirred at room temperature for 48 hours.Further piperidine (4 muL, 0.04 mmol) and acetic acid (1 drop) were added and the mixture was stirred at room temperature for 20 hours.Further piperidine (4 muL, 0.04 mmol) and acetic acid (1 drop) were added and the mixture was stirred at room temperature for 96 hours.The solvent was evaporated under reduced pressure and toluene was added and evaporated under reduced pressure.The residue was dissolved in acetic acid (2 ML), palladium on carbon (5%, 20 mg) was added and the mixture was stirred under an atmosphere of hydrogen (1 Atm.) for 16 hours.The mixture was filtered and poured onto an SCX cartridge (Varian Bond Elut; 10 ML/500 mg).The cartridge was washed with methanol (4*2 ML), then eluted with methanolic ammonia (2K, 2*2 ML).The solvent was evaporated under reduced pressure and the residue was purified by preparative thin layer chromatography on silica gel, eluding with CH2Cl2/MeOH/NH3(Aq.) (200:8:1), to give the title compound as a colorless glass (1.4 mg, 6%).1H NMR (360 MHz, CD3OD) delta 0.88-4.91 (5H, m), 1.28-1.65 (10H, m), 1.86-1.94 (2H, m), 2.05-2.08 (1H, m), 2.33-2.40 (1H, m), 2.55-2.72 (4H, in), 2.77-2.81 (2H, m), 2.92-3.13 (3H, m), 3.75 (1H, q, J 7.0 Hz), 4.46 (1H, m), 7.18 (1H, t, J 7.2 Hz), 7.24-7.29 (1H, m), 7.44-7.46 (2H, m), 7.72 (2H, s), and 7.78 (1H, s).m/z (ES+) 624 (M+1).
The synthetic route of 6091-44-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John; US2003/236250; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem