With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5382-17-2,Piperidin-4-ol hydrochloride,as a common compound, the synthetic route is as follows.
a 4-Benzyl-5-bromo-2-(4-hydroxypiperidino)pyridine A mixture of 550 mg of 4-benzyl-5-bromo-2-pyridyl trifluoromethanesulfonate (Production Example 1), 600 mg of 4-hydroxypiperidine hydrochloride, 1 ml of triethylamine and 2 ml of N,N-dimethylformamide was heated under stirring for 3 hours in an oil bath kept at 100 C. in a nitrogen atmosphere. After cooling as it was, the reaction mixture was extracted with ethyl acetate/water. The organic phase was washed with water and brine, dried over anhydrous magnesium sulfate and evaporated. The residue was subjected to silica gel column chromatography and eluted with 50% ethyl acetate/hexane, to give 270 mg of the target compound. 1H-NMR (CDCl3) delta=1.44-1.60 (2H, m), 1.88-1.97 (2H, m), 3.03-3.12 (2H, m), 3.75-3.96 (3H, m), 3.99 (2H, s), 6.41 (1H, s), 7.19 (2H, d, J=7 Hz), 7.25 (1H, t, J=7 Hz), 7.32 (2H, t, J=7 Hz), 8.20 (1H, s)., 5382-17-2
The synthetic route of 5382-17-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Eisai Co., Ltd.; US6599917; (2003); B1;,
Piperidine – Wikipedia
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