495414-81-8, 1-tert-Butyl 4-ethyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of compound c (2.54 g, 8.6 mmol), cobalt chloride hexahydrate (1.02 g, 4.3 mmol) and methanol (50 mL) was added sodium borohydride (1.63 g, 43.1 mmol) under ice-cooling, and the mixture was stirred under ice-cooling for 2 h, and then at room temperature for 2 days, and then 60C for 2 h. Aqueous ammonia (28%, 5 mL) was added thereto, the precipitate was removed by filtration, and the filtration was extract with ethyl acetate(3×40 mL). The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography eluting with ethyl acetate to obtain the desired product d (0.83 g) as a white powder, yield: 39.3%, mp: 153.2-154.4C. 1H NMR (600 MHz, DMSO) delta 7.56 (s, 1H, CONH), 3.81 (d, J = 12.0 Hz, 2H, diazaspiro-CH2), 3.17 (t, J = 6.8 Hz, 2H, diazaspiro-CH2), 2.90 (s, 2H, diazaspiro-CH2), 1.95 (t, J = 6.8 Hz, 2H, diazaspiro-CH2), 1.54-1.48 (m, 2H, diazaspiro-CH2), 1.40 (s, 9H, C(CH3)3), 1.31 (d, J = 13.2 Hz, 2H, diazaspiro-CH2). 13C NMR (151 MHz, DMSO) delta 181.62, 154.68, 79.48, 41.97, 40.58, 38.72, 32.00, 31.82, 28.43. HRMS(ESI): calcd for C13H22N2O3 [M+Na]+, 277.1523, found, 277.1523.
495414-81-8, As the paragraph descriping shows that 495414-81-8 is playing an increasingly important role.
Reference：
Article; Li, Bing; Wang, Kaiyuan; Zhang, Rui; Li, Baihui; Shen, Yangli; Ji, Qinggang; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem