Simple exploration of 4897-50-1

4897-50-1, As the paragraph descriping shows that 4897-50-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4897-50-1,4-Piperidinopiperidine,as a common compound, the synthetic route is as follows.

Example 61; 7-(l,4′-bipiperidin-r-ylV5-chloro-l-(2,6-difluorophenylV3,4-dihvdropyrimido[4.5- ^pyrimidin-2(‘l.H)-one )To a solution of 5-chloro- 1 -(2,6-difluorophenyl)-7-(methylsulfinyl)-3 ,A- dihydropyrimido[4,5-d]pvrimidin-2(lH)-one (200 mg, 0.56 mmol) in DCM (10 mL) were added 1 ,4’-bipiperidine (270 mg, 1.61 mmol) and AzetaN-diisopropylethylamine (0.3 mL, 1.7 mmol). The resultant solution was stirred at room temperature over night. The result mixture was concentrated. CombiFlash chromatography (mobile phase DCM/DCM[90]+MeOH[7]+NuH4OH[3]) provided the title compound as a white solid (298 mg, 83 percent). LC-MS m/z 463 (M + H)+.

4897-50-1, As the paragraph descriping shows that 4897-50-1 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/104917; (2006); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem