42538-31-8,42538-31-8, (S)-3-Aminopiperidin-2-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
ExamEleJj_(5)-3-(l’-Methylcyclohexanecarbonyl)amino-tetrahydropyridin-2-one; (S)-3-Amino-tetrah.ydropyridin-2-one hydrochloride (2 mmol) and Na2CO3 (6 mmol) in water (25 ml) were added to a solution of 1-methylcyclohexanecarbonyl chloride (2 mmol) in dichloromethane (25 ml) at ambient temperature and the reaction was stirred for 18 hours. The organic layer was then separated and the aqueous phase was extracted with additional dichloromethane. The combined organic layers were dried over Na2SO4 and reduced in vacuo. The residue was purified by silica column chromatography (EtOAc: hexanes 1:3 to MeOH : EtOAc 1:19) to give as an amorphous solid (199 mg, 42%); v^/cm”1 3335, 3269 (NH)5 1650, 1621 (CO), 1529 (NH); deltaH (500 MHz, CDCl3) 6.65 (IH5 br d, J5, NH), 6.59 (IH5 br S5 NH), 4.18 (IH5 dt, J 11.5, 5.5, CHNH), 3.30 (2H, td, J6.5, 2.5, CH2NH), 2.52 (IH, ddt, J 13, 5.5, 4.5, lactam CH2), 1.92-1.83 (4H5 m, 2 x lactam CH and 2 x cyclohexane CH2), 1.55-1.23 (9H, m, lactam CH and 8 x cyclohexane CH2) and 1.11 (3H, s, CH3); deltac (125 MHz, CDCl3) 178.0, 172.3 (CO)5 50.4 (NHCHCO), 42.6 (CH3C quat), 41.5, 35.6, 35.5, 27.0 (CH2), 26.3 (CH3), 25.7, 22.8 (chi2), 20.9 (CH2); m/z (MNa+ C13H22N2O2Na requires 261.1579) 261.1570.
42538-31-8 (S)-3-Aminopiperidin-2-one hydrochloride 45789910, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED; WO2006/134385; (2006); A2;,
Piperidine – Wikipedia
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