With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3612-20-2,1-Benzylpiperidin-4-one,as a common compound, the synthetic route is as follows.
To a mixture of N-benzylpiperidin-4-one 1 (0.01 mol, 1.89 g), aniline (0.01 mol), and activated zinc (0.04 mol), 90% aqueous acetic acid (0.16 mol) was added in portions. The mixture was stirred at room temperature for 24 h and at 70C on a water bath for an additional 12 h. After the reaction completion, the mixture was diluted with methanol and filtered. The filtrate was concentrated in a vacuum and then neutralized with a 30% ammonium hydroxide solution to pH 10. The crude product was collected by filtration and recrystallized with petroleum ether to obtain the pure product in 84% yield (2.2 g). IR (KBr), nu, cm-1: 3440 (N-H stretching), 3255, 3020, 2936, 2842,1615, 1526, 1490, 1372, 1318,1255, 1087, 977, 862, 751, 690. 1H NMR [400 MHz,CDCl3, delta (ppm)]: 1.50 (dq, 2H), 2.10 (br.d, 2H), 2.30(br.t, 2H), 2.60 (s, 2H), 2.90 (br.d, 2H), 3.35 (m, 1H),3.50 (br.s, 1H), 7.10-7.40 (m, Ar-H). Mass spectrum(m/z): 267 [M + 1]., 3612-20-2
The synthetic route of 3612-20-2 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Nami; Dabiri; Shirvani; Ahmadi Faghih; Javaheri; Radiochemistry; vol. 60; 1; (2018); p. 42 – 44; Radiokhimiya; vol. 60; 1; (2018); p. 42 – 44,4;,
Piperidine – Wikipedia
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