With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.309956-78-3,(R)-tert-Butyl piperidin-3-ylcarbamate,as a common compound, the synthetic route is as follows.
Reaction of l-[4-chloro-6-(4-morpholinyl)-l,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-lH-benzimidazole with ter/-butyl (3lambda)-piperidinylcarbamate gave tert-butyl (3R)- 1 -[4-[2-(difluoromethyl)-4-methoxy- 1 H-benzimidazol- 1 -yl]-6-(4- morpholinyl)-l,3,5-triazin-2-yl]piperidinylcarbamate in 94 % yield: mp (Ceta2Cl2/hexanes) 115-118 0C; 1H nuMR (DMSO-^6) (retainers) delta 8.00 and 7.89 (2d, J = 8.1, 8.4 Hz, IH), 7.72 and 7.69 (t, JH? = 52.6, 52.7 Hz, lH),7.43-7.36 (m, IH), 6.95 (d, J = 7.9 Hz, IH), 6.95 (br, exchangeable with D2O, IH), 4.53-4.43,4.37-4.31 and 4.21-4.13 (3m, IH), 3.97 (s, 3H), 3.79 (m, 4H), 3.69 (m, 4H), 3.42-3.36 (m, 2H), 3.16-3.10 and 3.02-2.96 (2m, 2H) 1.88-1.79 (m, 2H), 1.55-1.40 (m, 2H), 1.40 and 1.38 (2s, 9H)., 309956-78-3
The synthetic route of 309956-78-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AUCKLAND UNISERVICES LIMITED; WO2009/120094; (2009); A2;,
Piperidine – Wikipedia
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