24537-50-6, 2-Oxopiperidine-4-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 2-oxopiperidine-4-carboxylic acid (21.3 g) in tetrahydrofuran (300 mL) was added 60% sodium hydride (18 g, containing mineral oil) under cooling to 0C. The reaction mixture was stirred for 30 min under cooling to 0C. To the reaction mixture was added dropwise 1- (bromomethyl) -2, 4-bis (trifluoromethyl) benzene (46 g) under cooling to 0C, and the mixture was further stirred at 80C for 2 days. Water was added to the reaction mixture under cooling to 0C, and the mixture was extracted with ethyl acetate. To the aqueous layer was further added 10% hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was dried over sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (32 g) .? NMR (400 MHz, CDC13) delta 2.03-2.09 (1H, m) , 2.18-2.24 (1H, m) , 2.81-2.82 (2H, m) , 2.97-3.01 (1H, m) , 3.28-3.31 (2H, m) , 4.66 (1H, d, J = 16.0 Hz), 5.10 (1H, d, J = 16.0 Hz), 7.50 (1H, d, J = 8.0 Hz), 7.78 (1H, d, J = 8.0 Hz), 7.91 (1H, s) .MS (ESI+) : [M+H]+ 370., 24537-50-6
24537-50-6 2-Oxopiperidine-4-carboxylic acid 55286080, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; MATSUMOTO, Shigemitsu; ONO, Koji; TOMINARI, Yusuke; KATOH, Taisuke; MIWA, Kazuhiro; HASUOKA, Atsushi; IMAMURA, Shinichi; WO2013/18929; (2013); A1;,
Piperidine – Wikipedia
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