221874-51-7, (R)-tert-Butyl (2-oxopiperidin-3-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
221874-51-7, Preparation of Compound 149Step 1:(S)-tert-Butyl (l-isopropyl-2-oxopiperidin-3-yl)carbamate. (5)-tert-butyl (2- oxopiperidin-3-yl)carbamate (1.21 g, 5.69 mmol) was dissolved in DMSO (12 mL). KOH (415 mg, 7.39 mmol) was added, followed by 2-iodopropane (740 mu,, 7.4 mmol) and the mixture stirred for 72 h. The reaction was quenched by addition of saturated aqueous NH4CI (8 vol) and extracted with EtOAc (2 x 4 vol). The combined extracts were washed with brine, dried, filtered and evaporated. The desired product was isolated by silica gel chromatography to afford tert-butyl N-[(3S)-l-isopropyl-2-oxo-3-piperidyl]carbamate. Yield: (430 mg, 29.5%). MS: m/z (obs.) 279.1 [M+Na . 1H NMR (400 MHz, d6- DMSO) delta 6.83 (d, J = 8.1 Hz, 1H), 4.68 – 4.52 (m, 1H), 3.88 (d, J = 6.8 Hz, 1H), 3.12 (dd, J = 13.0, 7.2 Hz, 2H), 1.98 – 1.85 (m, 1H), 1.75 (dd, J = 12.3, 6.8 Hz, 2H), 1.56 (d, J = 17.8 Hz, 1H), 1.38 (s, 11H), 1.03 (dd, J = 6.7, 2.0 Hz, 7H).
The synthetic route of 221874-51-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; VERTEX PHARMACEUTICALS INCORPORATED; GREEN, Jeremy; WILSON, Dean, M.; KONG, Laval, Chan Chun; DAS, Sanjoy, Kumar; POISSON, Carl; COURT, John, J.; TANG, Qing; LI, Pan; COLLIER, Philip, N.; WAAL, Nathan; LAUFFER, David, J.; DORSCH, Warren; WO2012/6055; (2012); A2;,
Piperidine – Wikipedia
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