With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2213-43-6,1-Aminopiperidine,as a common compound, the synthetic route is as follows.
To a magnetically stirred solution of 6 (4.40 g, 9.24 mmol) and aluminum trichloride (2.46 g, 18.48 mmol) in dichloride ethane (88 mL) was added 1-aminopiperidine (3.70 g, 36.96 mmol) slowly under argon at 0 C. The resulting mixture was allowed to warm up to room temperature and stirred for 16 h, then quenched with ice water. The aqueous phase was extracted with CH2Cl2 (2*40 mL). The combined organic extracts were washed with water and brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give crude residue, which was purified by flash chromatography eluting with n-hexane/ethyl acetate (1:1) to afford Compound 7 (4.75 g, 97%) as a white solid: 1H NMR (CDCl3) delta 7.73 (s, 1H), 7.49 (d, J=2.4 Hz, 1H), 7.35 (dd, J=8.4, 2.4 Hz, 1H), 7.28 (d, J=8.4 Hz, 1H), 6.95 (d, J=4.0 Hz, 1H), 6.69 (d, J=4.0 Hz, 1H), 5.17 (t, J=7.2 Hz, 1H), 4.67 (d, J=7.2 Hz, 2H), 2.83 (brs, 4H), 1.78-1.73 (m, 4H), 1.42 (brs, 2H); 13C NMR (CDCl3) delta 160.0, 144.7, 136.9, 136.6, 135.0, 133.6, 130.7, 130.3, 130.2, 128.6, 128.1, 124.0, 115.8, 57.1, 54.7, 25.3, 23.2; ESMS m/z: 529.1 (M+1).
2213-43-6 1-Aminopiperidine 16658, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; National Health Research Institutes; Shia, Kak-Shan; Chang, Chun-Ping; Chao, Yu-Sheng; US2013/85126; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem