With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19099-93-5,1-Cbz-Piperidin-4-one,as a common compound, the synthetic route is as follows.
To a stirred solution of benzyl 4-oxopiperidine-l-carboxylate (2.37 g, 10.17 mmol) in EtOH (50 mL) at 0 0C under a nitrogen atmosphere was added NaBH4 (0.42 g, 11.19 mmol) in one portion. The reaction mixture was warmed to RT and stirred for 2 h. The resulting reaction mixture was cooled to O0C and aqueous ammonium chloride (20 mL) added. The solvent was evaporated at reduced pressure, aqueous phase extracted with DCM (3 x 20 mL), organics separated, combined, dried (MgSO4), filtered and concentrated to give colourless oil (2.39 g, 100 % yield). The title compound was used without further purification. LCMS data: Calculated MH+ (236.29); Found 66% (MH+) m/z 236.21, Rt = 3.69 min. 1H NMR (250 MHz, CHLOROFORM-J) delta ppm 7.29 – 7.58 (5 H, m), 5.13 (2 H, s), 3.77 – 4.10 (3 H, m), 3.02 – 3.30 (2 H, m), 1.73 – 1.98 (2 H, m), 1.39 – 1.69 (3 H, m)., 19099-93-5
As the paragraph descriping shows that 19099-93-5 is playing an increasingly important role.
Reference：
Patent; EVOTEC NEUROSCIENCES GMBH; WO2009/121812; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem