19099-93-5, 1-Cbz-Piperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step B. Ben2yl 7′-chloro-2′-oxo-r,2′-dihydro-lH-spiro[piperidine-4,4′-pyrido[2,3- ][l,3]oxazme]-l-carboxylate; To a -20 C solution of N,iV;N',N'-tetramethylethylenediamine (22.3 mL, 147.6 mmol) in tetrahydrofuran (180 mL) was added ?-butyllithium (2.5 M; 59.0 mL, 147.6 mmol) over 10 min. After 30 min, the mixture was cooled to -78 C and tert-butyl (6-chloropyridin-2- yl)carbamate (15.0 g, 65.6 mmol) in tetrahydrofuran (60 mL) was added over 15 min. After 2.5 h, a solution of iV-benxyloxycarbonyl-4-piperidinone (23.0 g, 98.4 mmol) in tetrahydrofuran (60 mL) was added over 10 min. The reaction was allowed to warm to ambient temperature. After 1 h, the reaction was heated to 40 0C. After 18 h, the mixture was quenched with saturated aqueous sodium bicarbonate and the mixture extracted with dichloromethane (3x). The combined organic extracts were washed with water, saturated brine, dried over magnesium sulfate, filtered, and concentrated. Recrystalization was accomplished by dissolving the crude residue in ethanol (450 mL) at 65 0C. The solution flask was placed in the freezer at -20 0C. After 18 h, the precipitated solid was filtered, washed with ether, dried to give the title compound (11.9 g). MS: mlz = 388.0 (M+l), 19099-93-5
The synthetic route of 19099-93-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK & CO., INC.; WO2006/44504; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem