189333-49-1, 3-Benzyl-3,9-diazaspiro[5.5]undecane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To 5 – fluoro -2 – nitroanisole (1.0 kg, 5 . 84 muM, 1 equivalent) and 3 – benzyl – 3, 9 – diaza spiro [5.5] undecane (1.70 kg, 5 . 57 muM, 0 . 95 equivalent) of N – methyl pyrrolidone (4 L) are added in the solution of the N, N – diisopropyl serotonin reuptake (1.13 kg, 8 . 77 muM, 1 . 55 equivalent) in the reaction liquid after 100 C under stirring for 4 hours. TLC (dichloromethane: methanol=6:1, Rf=0.5) display the reaction is complete. After the reaction cooled to room temperature water (16 L) is slowly added to the reaction solution, a large number of solid precipitation, suspension to continue stirring 1 hour after-filtration, the filter cake is added to ethanol (5 L) in, reflux beating 1 hour, cooling to room temperature and filtered. The flotation cake re-ethanol (5 L) reflux beating, then filtered, the filter cake drying to obtain the product (1.92 kg, 83% yield) as a yellow solid.
189333-49-1, As the paragraph descriping shows that 189333-49-1 is playing an increasingly important role.
Reference：
Patent; Qilu Pharmaceutical Co., Ltd.; Ding Zhaozhong; Chen Shuhui; Liu Xile; Wan Haiwen; Zhang Lu; (27 pag.)CN106928275; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem