177948-02-6, tert-Butyl N-[(4-hydroxypiperidin-4-yl)methyl]carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1- [ (1, L-DIMETHYLETHOXYCARBONYL) AMINO]-PIPERIDINE-4-CARBOXYLIC acid (6g, 26. 16mmol, leq. ), from stepl, was dissolved in methanol (150ml) and cesium carbonate (4.26g, 13. 08mmol, 0. 5eq.) was added. The mixture was stirred at room temperature for 2h, the the solvent was removed under reduced pressure. The crude was dissolved in DMF (100ML) and benzylbromide (5.37g, 31.39mmol, 1. 2eq. ) was added dropwise. The mixture was stirred overnight at room temperature and poured in water (300ml), extracted with Ethyl Acetate (900ML) The organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure to give a white solid. Yield 95%, 7G. Analytical data: H NMR (DMSO-d6) 7.3 (5H m); 5.1 (2H, s); 3.85 (2H, d); 2.8 (2H, br); 2.65 (1H, t); 1.8 (2H, d) ; 1.4 (llH, m).
177948-02-6, 177948-02-6 tert-Butyl N-[(4-hydroxypiperidin-4-yl)methyl]carbamate 10868112, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; CEPHALON, INC.; SEDE SECONDARIA DELLA CELL THERAPEUTICS, INC.; WO2005/21558; (2005); A2;,
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