Simple exploration of 170737-53-8

170737-53-8 Methyl N-Cbz-4-piperidineacetate 40429392, apiperidines compound, is more and more widely used in various fields.

170737-53-8, Methyl N-Cbz-4-piperidineacetate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step B: Benzyl 4-[l-fmethoxycarbonyl)-3-phenylbut-3-en-l-yl]piperidine-l-carboxylate; Lithium hexamethyldisilylazide (1.0 M in THF; 7.31 mL, 7.31 mmol) was added to solution of benzyl 4-(2-methoxy-2-oxoethyl)piperidine-l-carboxylate (1.94 g, 6.65 mmol) in tetrahydrofuran (35 mL) at -78 0C. After 40 min, [l-(bromomethyl)vinyl]benzene (1.08 mL, 7.31 mmol) was added and the reaction mixture was warmed to ambient temperature. After 18 h, the mixture was quenched with saturated aqueous ammonium chloride and extracted with ethyl acetate (2x). The combined organic extracts were dried over magnesium sulfate, filtered and concentrated. Purification by silica gel chromatography (100% hexanes -? 40% hexanes/ ethyl acetate) gave the title compound (2.11 g). MS 408.2 (M+l)., 170737-53-8

170737-53-8 Methyl N-Cbz-4-piperidineacetate 40429392, apiperidines compound, is more and more widely used in various fields.

Reference:
Patent; MERCK & CO., INC.; WO2006/44504; (2006); A1;,
Piperidine – Wikipedia
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