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2? Biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR
Biaryl amides were discovered as novel and subtype selective M1 muscarinic acetylcholine receptor agonists. The identification, synthesis, and initial structure-activity relationships that led to compounds 3j and 4c, possessing good M1 agonist potency and intrinsic activity, and subtype selectivity for M1 over M2-5, are described.
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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H17120N – PubChem