The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Boc-4-(Aminomethyl)piperidine(SMILESS: NCC1CCN(C(OC(C)(C)C)=O)CC1,cas:144222-22-0) is researched.Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate. The article 《Syntheses and Binding Testing of N1-Alkylamino-Substituted 2-Aminobenzimidazole Analogues Targeting the Hepatitis C Virus Internal Ribosome Entry Site*》 in relation to this compound, is published in Australian Journal of Chemistry. Let’s take a look at the latest research on this compound (cas:144222-22-0).
A series of 2-aminobenzimidazole analogs have been synthesized and tested for binding to a previously established RNA target for viral translation inhibitors in the internal ribosome entry site (IRES) of the hepatitis C virus (HCV). Synthesis of new inhibitor compounds followed a highly convergent strategy which allowed for incorporation of diverse tertiary amino substituents in high overall yields (eight-steps, 4-22%). Structure-activity relationship (SAR) studies focussed on the tertiary amine substituent involved in hydrogen bonding with the RNA backbone at the inhibitor binding site. The SAR study was further correlated with in silico docking experiments Analogous compounds showed promising activities (half maximal effective concentration, EC50: 21-89μM). Structures of the synthesized analogs and a correlation to their mode of binding, provided the opportunity to explore parameters required for selective targeting of the HCV IRES at the subdomain IIa which acts as an RNA conformational switch in HCV translation.
Different reactions of this compound(1-Boc-4-(Aminomethyl)piperidine)Synthetic Route of C11H22N2O2 require different conditions, so the reaction conditions are very important.
Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem