With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.140645-24-5,(S)-3-(Aminomethyl)-1-N-Boc-piperidine,as a common compound, the synthetic route is as follows.
4 (0.30 g, 0.92 mmol) was dissolved in 20 mL of ethanol,(S) -1-Boc-3-aminomethylpiperidine (0.26 g, 1.20 mmol) and DIPEA (0.18 mL, 1.01 mmol)Reflux reaction 48h,Ethyl acetate dissolved, suction filter,Purification by column chromatography [P: E = 1: 1 (V: V)] gave 0.24 g of a pale yellow solid in 51.8% yield., 140645-24-5
The synthetic route of 140645-24-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; China Pharmaceutical University; Lai Yisheng; Zhang Yingyi; Xiao Jianhu; Jin Shuanglong; Li Yuezhen; Zhang Yihua; (31 pag.)CN107043366; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem