Chemistry is an experimental science, Quality Control of: tert-Butyl 4-formylpiperidine-1-carboxylate, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 137076-22-3, Name is tert-Butyl 4-formylpiperidine-1-carboxylate
Using a site-directed fragment discovery method called tethering, we have identified a 60 nM small molecule antagonist of a cytokine/receptor interaction (IL-2/IL2Ralpha) with cell-based activity. Starting with a low micromolar hit, we employed a combination of tethering, structural biology, and computational analysis to design a focused set of 20 compounds. Eight of these compounds were at least 5-fold more active than the original hit. One of these compounds showed a 50-fold enhancement and represents the highest affinity inhibitor reported against this protein-protein target class. This method of coupling selected fragments with a low micromolar hit shows great potential for generating high-affinity lead compounds. Copyright
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of: tert-Butyl 4-formylpiperidine-1-carboxylate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 137076-22-3, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H15990N – PubChem