With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.135632-53-0,tert-Butyl (piperidin-4-ylmethyl)carbamate,as a common compound, the synthetic route is as follows.
General procedure: NaBH(OAc)3 (typically 1.4 eq) was added to a solution of amine 5 (typically 1.0 eq) and aldehyde (typically 1.0 eq) in 1,2-dichloroethane (DCE). The mixture was stirred at rt until the conversion was finished as judged by TLC and LC/MS analyses. The reaction mixture was quenched with 10% K2CO3 aqueous solution. The product was extracted with dichloromethane (DCM) (3x). The combined organic layers were washed with brine (1x). Subsequently, the organic layer was dried with anhydrous Na2SO4. The solvent was removed in vacuo to give crude product which was purified by flash column chromatography. Unless mentioned otherwise, cyclohexane/5% TEA: EtOAc/5%TEA and a gradient flow from 100-0% to 50-50% were used.
135632-53-0, The synthetic route of 135632-53-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Adlere; Sun; Zarca; Roumen; Gozelle; Viciano Perpina; Caspar; Arimont; Bebelman; Briddon; Hoffmann; Hill; Smit; Vischer; Wijtmans; de Graaf; de Esch; Leurs; European Journal of Medicinal Chemistry; vol. 162; (2019); p. 631 – 649;,
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