With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.122860-33-7,Benzyl 4-(hydroxymethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
Reference Example 2 N-CBZ-4-iodomethylpiperidine This compound is prepared according to the procedure disclosed in U.S. Pat. No. 5,538,984. Triphenylphosphine (31.2 gr) was added to a mixture of iodine (29.4 g) in toluene (1L). After 5 min, pyridine (18 ml) was added, followed by CBZ-piperidinemethanol (34.6 gr). The resulting mixture was heated and stirred at reflux for 1.5 h. The reaction mixture was allowed to cool to room temperature, and filtered. The filtrate was washed with saturated sodium metabisulfite and brine. The organic layer was dried over MgSO4 and evaporated. The crude product was dissolved in ethyl acetate/hexane 1:5, and filtered through silica gel. The filtrate was evaporated under reduced pressure, and the crude product was crystallized from ethyl acetate/hexane., 122860-33-7
The synthetic route of 122860-33-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; CHEMAGIS LTD; US2004/48893; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem