With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1187173-43-8,2,7-Diazaspiro[4.5]decan-1-one hydrochloride,as a common compound, the synthetic route is as follows.
To a solution of 2,7-diazaspiro[4.5]decan-1-one hydrochloride (1.0 g, 5.26 mmol) in DCM (10 mL), benzaldehyde (0.53 mL, 5.26 mmol) was added and the mixture was stirred at RT for 15 mm, then NaBH(OAc)3 (1.67 g, 7.89 mmol) was added and the mixture was left stirring at RT overnight. Thereaction was quenched with saturated NaHCO3 solution, then phases were separated and aqueous one was backextracted with DCM twice. Combined organics were washed with brine, dried and concentrated under reduced pressure. Crude material was purified by FC on NH column (eluent: Cy to 50% AcOEt) affording 7-benzyl-2,7-diazaspiro[4.5]decan-1-one (p139, 890 mg, y= 69%) as white solid. MS (ES) (m/z): 245.2 [M÷H], 1187173-43-8
The synthetic route of 1187173-43-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SHIRE INTERNATIONAL GMBH; CREMONESI, Susanna; LUKER, Tim; SEMERARO, Teresa; MICHELI, Fabrizio; (257 pag.)WO2016/42452; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem