With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1171080-45-7,(2S,5R)-Benzyl 5-((benzyloxy)amino)piperidine-2-carboxylate oxalate,as a common compound, the synthetic route is as follows.
Example 2aBenzyl (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxylate ethanedioate (1:1) (50 g, 113.8 mmol) was mixed with a solution of ammonia in methanol (7N, 700 ml) and agitated until the reaction was deemed to be complete. The mixture was filtered to remove ammonium oxalate byproduct, the ammonium oxalate cake was washed with methanol (2¡Á50 ml) and the combined filtrates were concentrated to 250 ml. Toluene (500 ml) was added and the solution was concentrated to 250 ml causing the product to precipitate. Toluene (500 ml) was added, and the mixture was heated to 80 C. and cooled to 0 C. The product was isolated by filtration, washed with methyl tert-butyl ether (MTBE) (100 ml), and dried to yield a white crystalline solid (26.9 g, 108 mmol, 95%).1H NMR (400 MHz, DMSO) deltaH 1.12 (1H, m), 1.27 (1H, m), 1.83 (2H, m), 2.22 (1H, dd), 2.76 (1H, m), 2.89 (1H, dd), 3.14 (1H, dd), 4.58 (2H, s), 6.46 (1H, d), 6.91 (1H, s), 7.09 (1H, s), 7.32 (5H, m).
1171080-45-7, The synthetic route of 1171080-45-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FOREST LABORATORIES HOLDINGS LTD.; US2012/323010; (2012); A1;,
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