With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1169563-99-8,tert-Butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
4- (5-amino -1H- pyrazol-3-yl) piperidine-1-carboxylic acid tert- butyl (compound described in WO2011 / 045344 pamphlet, 13.5 g, 50.7 mmol) ethyl acetate (60 mL) to the solution under cooling with ice, it was added dropwise hydrochloric acid (4M in dioxane, 31.7mL, 127mmol), followed by stirring at room temperature for 3 hours.After stirring for 10 minutes by adding ethyl acetate (40 mL) to the reaction solution, and collected by filtration and the resulting precipitate to give the title compound (12.5 g, yield: 100%) was obtained., 1169563-99-8
The synthetic route of 1169563-99-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Daiichi Sankyo company limited; Sato, Rie; Kobayashi, Katsuhiro; Kaneko, Toshio; (188 pag.)JP2015/113323; (2015); A;,
Piperidine – Wikipedia
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