Simple exploration of 1147423-01-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1147423-01-5,tert-Butyl 7-acetyl-2,7-diazaspiro[3.5]nonane-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of 2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester (70 mg,0.309 mmol) in DCM (3 mL) were added acetyl chloride (32 muL, 0.450 mmol) and triethylamine (54 muL, 0.526 mmol). The resulting mixture was stirred at RT for 2 h. The reaction mixture was loaded onto an Isolute SCX-2 cartridge, and washed with MeOH then eluted with 2 M NH3 in MeOH to give 7-acetyl-2,7-diaza-spiro[3.5]nonane-2-carboxylic acid ester. To a solution of 7-acetyl-2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert- butyl ester in DCM (3 mL) was added TFA (1 mL) and the resulting mixture was stirred at RT for 1 h. The reaction mixture was loaded onto an Isolute SCX-2 cartridge, washed with MeOH then eluted with 2 M NH3 in MeOH to give the title compound as a colourless oil (41 mg, 79 %).1H NMR (400 MHz, CDCl3): delta 1.69-1.79 (m, 2 H), 1.78-1.83 (m, 2 H), 2.08 (s, 3 H), 3.32- 3.37 (m, 2 H), 3.39-3.45 (m, 2 H) and 3.37-3.57 (m, 4 H)., 1147423-01-5

The synthetic route of 1147423-01-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2009/53715; (2009); A1;,
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