With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1089279-91-3,1-(4-Amino-3-methoxyphenyl)-N,N-dimethylpiperidin-4-amine,as a common compound, the synthetic route is as follows.
To n-butanol (2 mL) was added compound 4A-5 (50 mg, 0.200 mmol) and compound 5A-2 (70 mg, 0.200 mmol), and then p-toluenesulfonic acid (35 mg, 0.200 mmol) was added under stirring. The mixture was heated to 100C and stirred for 5 hours. After TLC indicated the reaction was completed, the reaction mixture was concentrated under reduced pressure to give a crude product, which was further purified and isolated by column chromatography to obtain an off-white solid product, compound I-6 (78 mg, yield 69.4%). 1H NMR (400 MHz, cd3od) delta 9.11 (d, J=6.9 Hz, 1H), 8.36-8.31 (m, 1H), 8.09 (d, J=3.6 Hz, 1H), 7.58-7.45 (m, 2H), 6.67 (t, J=2.8 Hz, 1H), 6.57-6.50 (m, 1H), 3.92-3.76 (m, 6H), 3.40-3.31 (m, 1H), 2.90 (s, 6H), 2.79 (m, 2H), 2.18 (m, 2H), 1.87 (m, 2H), 1.29 (t, J=6.6 Hz, 6H). LCMS: t=0.807 min, 559.2 (M), 560.2 (M+1)
1089279-91-3, The synthetic route of 1089279-91-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Humanwell Healthcare (Group) Co., Ltd.; WANG, Xuehai; XU, Yong; SHENG, Xijun; ZHANG, Xiaolin; XIA, Hangui; YANG, Zhongwen; YUE, Yang; HUANG, Lu; XIAO, Qiang; (80 pag.)EP3372594; (2018); A1;,
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