With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1062580-52-2,(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride,as a common compound, the synthetic route is as follows.
20g of compound 5,13.3g of compound 4 is added to the 500ml reaction flask,Add 266 ml of purified water,Add pre-mixed potassium carbonate solution with stirring(20 g of potassium carbonate was dissolved in 40 ml of purified water) and heated to reflux.After stirring and refluxing for 10 hours, TLC detection was started until the reaction was completed.Cool down to 20 ~ 30 C, add 120ml dichloromethane and stir to extract.The mixture was allowed to stand, dried, filtered, and washed to obtain a reaction solution.Add n-heptane with stirring at room temperature.Decreasing to 0 to 10 C for 2 to 4 hours,Filter and wash. Drying at 50-60 C for 6 hours under vacuum to obtain compound 3,Weighing 20.9g,Yield: 82.3%, purity: 99.9%., 1062580-52-2
The synthetic route of 1062580-52-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Qilu Tianhe Huishi Pharmaceutical Co., Ltd.; Li Fadong; Wu Ke; Yang Qingkun; Li Zhuohua; Zhou Xianfeng; Pan Guangpeng; (7 pag.)CN108276414; (2018); A;,
Piperidine – Wikipedia
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