1037834-62-0, 6-Azaspiro[2.5]octane hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
6-(chloroacetyl)-6-azaspiro[2.5]octane; Dissolved 6-azoniaspiro[2.5]octane chloride (1.1g, 7.5 mmol) and 2N sodium carbonate (9.3 ml, 19 mmol) in DCM (10 ml) while stirring in an ice bath. Slowly added 2- chloroacetyl chloride (0.712 ml, 9 mmol) dropwise and stirred cold for 30 minutes. The reaction mixture was stirred at room temperature for 1 h, and subsequently was diluted with dichloromethane (DCM, 20 ml) and water (20 ml). Separated layers and extracted aqueous layer twice with DCM. Combined organics were washed with brine, dried over sodium sulfate, filtered, and concentrated to yield pale-yellow oil (1 ,39g, 99%).Experimental Data; LCMS 50% H2O, Retention time 1.916 min., Parent C9Hi4CINO, MW 187.08; Found APCI+ 188.1 (M+1); 1H NMR (CDCI3) delta 4.05 (s, 2H), 3.7-3.4 (m, 4H), 1.50-1.30 (m, 4H), 0.35 (s, 4H)., 1037834-62-0
1037834-62-0 6-Azaspiro[2.5]octane hydrochloride 54593187, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; PFIZER PRODUCTS INC.; WO2008/84300; (2008); A1;,
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