With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.
10338-57-5, General procedure: In a 100-mL round-bottom flask, ethyl 2-(7-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo- 2H-benzo[b][1,4]oxazin-4(3H)-yl)acetate (22) (1 g, 3.03 mmol, 1 equivalent) and triphenylphosphine (0.87 g, 3.33 mmol, 1.1 equivalent) were dissolved in ethanol (50 mL). After stirring at 25 C for 10-15 min, aromatic aldehyde (3.03 mmol, 1 equivalent) was added slowly along with stirring. The reaction mixture was allowed to stir for 24 h. The progress of the reaction was monitored by TLC (MeOH:CHCl3::1:19). On completion of the reaction, the solvent was evaporated under reduced pressure. The solid residue so obtained was purified by column chromatography (MeOH:CHCl3::1:49) to afford the desired benzoxazine-based arylidinyl succinimide derivative (23-36) in 64-80% isolated yield.
As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.
Reference：
Article; Sharma, Atul K.; Prasad, Suchita; Sharma, Sunil K.; Synthetic Communications; vol. 47; 20; (2017); p. 1854 – 1863;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem